Management of Metabolic Dysfunction-Associated Steatotic Liver Disease with Lifestyle Modification.

Weight reduction (≥5% to improve steatosis and ≥7-10% to improve inflammation and fibrosis) through lifestyle modifications is a first-line treatment of metabolic dysfunction-associated steatotic liver disease. Although the Mediterranean diet is the most evidence-based and recommended diet, similar plant-based diets are also acceptable. Physical activity and exercise (aerobic and resistance) are effective in steatosis reduction, independent of weight loss. However, the uptake of lifestyle interventions is challenging, and to enhance adherence, clinicians, policymakers, and stakeholders should support individuals by increasing awareness and promoting a healthier environment. Behavioral support, personalization, and sustainability of recommendations are key factors in individualized treatment.