Медицинская библиотека · Annals of medicine · 2025

Mortality of Pneumocystis jirovecii pneumonia in intensive care units: a post-hoc analysis of an international multicenter study by ESGCIP and EFISG.

Giacobbe Daniele Roberto, Dettori Silvia, Di Pilato Vincenzo, Asperges Erika, Ball Lorenzo, Berti Enora, Blennow Ola, Bruzzone Bianca, Calvet Laure, Capra Marzani Federico, Casabella Antonio, Choudaly Sofia, Dartevel Anais, De Pascale Gennaro, Di Meco Gabriele, Fallon Melissa, Galerneau Louis-Marie, Gallego Miguel, Giacomini Mauro, González Saez Adolfo, Hänsel Luise, Icardi Giancarlo, Koehler Philipp, Lagrou Katrien, Lahmer Tobias, Lewis White Philip, Magnasco Laura, Marchese Anna, Marelli Cristina, Marín Arriaza Mercedes, Martin-Loeches Ignacio, Mekontso-Dessap Armand, Mikulska Malgorzata, Muccio Marco, Mularoni Alessandra, Nordlander Anna, Poissy Julien, Russelli Giovanna, Signori Alessio, Tascini Carlo, Vaconsin Louis-Maxime, Vargas Joel, Vena Antonio, Wauters Joost, Pelosi Paolo, Timsit Jean-Francois, Bassetti Matteo, JIR-ICU Investigators (Collaborators), the Critically Ill Patients Study Group of the European Society of Clinical Microbiology and Infectious Diseases (ESGCIP), and the Fungal Infections Study Group of the European Society of Clinical Microbiology and Infectious Diseases (EFISG), JIR-ICU investigators (collaborators)

СтатьяМногоцентровое исследованиеПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

BACKGROUND

Pneumocystis jirovecii pneumonia (PJP) is a life-threatening disease. In the intensive care unit (ICU), PJP is most frequently observed among patients with several conditions not related to the human immunodeficiency virus (HIV) infection.

METHODS

The primary objective of the present post-hoc analysis of a multicenter, multinational, retrospective study was to assess factors impacting prognosis in ICU patients with PJP through univariable and multivariable analyses.

RESULTS

A total of 107 patients were included; 28 had proven PJP (26.2%), and 79 had presumptive PJP (73.8%). The overall 30-day mortality was 52.7% (95% confidence interval [CI] 42.1-62.2). In the multivariable analysis, metastatic solid tumor (hazard ratio [HR] 3.49; 95% CI 1.71-7.13, p < 0.001) and chronic liver disease (HR 2.44; 95% CI 1.03-5.80, p = 0.044) showed an independent association with 30-day mortality. The direction of effect remained consistent when center was added to the multivariable model as random effect.

CONCLUSION

PJP mortality remains high in ICU patients. Conditions other than HIV infection are emerging not only as non-classical risk factors for PJP development, but also as important mortality predictors. A better understanding of the reasons underlying this evolving landscape could be crucial to improve PJP management and survival.

Для цитирования: Giacobbe Daniele Roberto, Dettori Silvia, Di Pilato Vincenzo, Asperges Erika, Ball Lorenzo, Berti Enora, Blennow Ola, Bruzzone Bianca, Calvet Laure, Capra Marzani Federico, Casabella Antonio, Choudaly Sofia, Dartevel Anais, De Pascale Gennaro, Di Meco Gabriele, Fallon Melissa, Galerneau Louis-Marie, Gallego Miguel, Giacomini Mauro, González Saez Adolfo, Hänsel Luise, Icardi Giancarlo, Koehler Philipp, Lagrou Katrien, Lahmer Tobias, Lewis White Philip, Magnasco Laura, Marchese Anna, Marelli Cristina, Marín Arriaza Mercedes, Martin-Loeches Ignacio, Mekontso-Dessap Armand, Mikulska Malgorzata, Muccio Marco, Mularoni Alessandra, Nordlander Anna, Poissy Julien, Russelli Giovanna, Signori Alessio, Tascini Carlo, Vaconsin Louis-Maxime, Vargas Joel, Vena Antonio, Wauters Joost, Pelosi Paolo, Timsit Jean-Francois, Bassetti Matteo, JIR-ICU Investigators (Collaborators), the Critically Ill Patients Study Group of the European Society of Clinical Microbiology and Infectious Diseases (ESGCIP), and the Fungal Infections Study Group of the European Society of Clinical Microbiology and Infectious Diseases (EFISG), JIR-ICU investigators (collaborators). Mortality of Pneumocystis jirovecii pneumonia in intensive care units: a post-hoc analysis of an international multicenter study by ESGCIP and EFISG.. Annals of medicine. 2025. DOI: 10.1080/07853890.2025.2511043.

Предметные рубрики MeSH

Humans Pneumonia, Pneumocystis Male Female Intensive Care Units Middle Aged Retrospective Studies Pneumocystis carinii Aged Risk Factors Prognosis Adult Hospital Mortality

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