Ocular immunology and inflammation · 2012
Infectious keratitis in severe limbal stem cell deficiency: characteristics and risk factors.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Sandali Otman, Gaujoux Thomas, Goldschmidt Pablo, Ghoubay-Benallaoua Djida, Laroche Laurent, Borderie Vincent M
Аннотация
PURPOSE: To evaluate the incidence, clinical and microbiological characteristics and risk factors of infectious keratitis in patients with limbal stem cell deficiency (LSCD).
METHODS: Retrospective comparative case series of 35 patients with severe LSCD.
RESULTS: The mean follow-up time was 46 months. Infectious keratitis were mainly caused by Gram positive bacteria (94%). Only 7 infections (37%) healed under fortified adapted antibiotics. In 8 cases (42%), amniotic membrane transplantation was required and in 4 cases (21%) «à chaud» keratoplasty was performed. Significant risk factors associated with infectious keratitis were: soft contact lens extended wear, history of persistent epithelial defects, number of quadrants of corneal vascularization, re-epithelialization time after amniotic membrane or corneal transplantation, and use of corticosteroid or cyclosporin eye drops.
CONCLUSION: Infectious keratitis in LSCD is frequent and severe. The restoration of the epithelial barrier integrity and a careful use of therapeutic contact lenses may help to prevent infection.
METHODS: Retrospective comparative case series of 35 patients with severe LSCD.
RESULTS: The mean follow-up time was 46 months. Infectious keratitis were mainly caused by Gram positive bacteria (94%). Only 7 infections (37%) healed under fortified adapted antibiotics. In 8 cases (42%), amniotic membrane transplantation was required and in 4 cases (21%) «à chaud» keratoplasty was performed. Significant risk factors associated with infectious keratitis were: soft contact lens extended wear, history of persistent epithelial defects, number of quadrants of corneal vascularization, re-epithelialization time after amniotic membrane or corneal transplantation, and use of corticosteroid or cyclosporin eye drops.
CONCLUSION: Infectious keratitis in LSCD is frequent and severe. The restoration of the epithelial barrier integrity and a careful use of therapeutic contact lenses may help to prevent infection.
Предметные рубрики MeSH
Adrenal Cortex HormonesAdultAgedAnti-Bacterial AgentsContact Lenses, HydrophilicCorneal TransplantationCyclosporineFemaleGram-Positive Bacterial InfectionsHumansImmunosuppressive AgentsIncidenceKeratitisLimbic SystemMaleMiddle AgedOphthalmic SolutionsRetrospective StudiesRisk FactorsSeverity of Illness IndexStem CellsVisual Acuity