Catching a ride: Nanoparticles bypass the blood-brain barrier.

Central nervous system drug delivery centers primarily on strategies aimed at crossing the blood-brain barrier. In a recent study, Gao et al.1 report that nanoparticles can bypass the blood-brain barrier by hijacking calvarial immune cells and exploiting migration through skull-meninges channels, which enables lesion-targeted, minimally invasive therapeutic delivery to the brain.