Clinical immunology (Orlando, Fla.) · 2017
Genetics of Sjögren's syndrome.
СтатьяОбзорResearch Support, N.I.H., IntramuralНазвание и аннотация: Перевод пока не подготовлен
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Teos Leyla Y, Alevizos Ilias
Аннотация
The pathogenesis of Sjögren's syndrome has not been elucidated. There has been evidence that genetics play an important role in the development of this disease from earlier studies. However, till now only a number of genes have been identified to be associated with SS, and these have only a weak or moderate effect. In this review we summarize the findings of the genetics studies and emphasize the need of large multicenter projects that will increase the sample sizes to provide more meaningful associations, as is the case in other common autoimmune diseases.
Предметные рубрики MeSH
B-Cell Activating FactorChemokine CCL11DNA-Binding ProteinsGenetic Predisposition to DiseaseGenome-Wide Association StudyHLA AntigensHumansInterferon Regulatory FactorsInterleukin-12 Subunit p35Lymphotoxin-alphaNatural Cytotoxicity Triggering Receptor 3OX40 LigandReceptors, CXCR5STAT4 Transcription FactorSerotonin Plasma Membrane Transport ProteinsSjogren's SyndromeTrans-ActivatorsTranscription Factors, TFIITumor Necrosis Factor alpha-Induced Protein 3src-Family Kinases