[Metabolism of the pesticide trichlorometaphos-3 and its effect on the monooxygenase system depending upon the supply of lysine, methionine, threonine and vitamins A, B and C].

Metabolism of organophosphate pesticide trichlorometaphos-3 and its effect on liver monooxygenase system were studied in male rats of WAG strain, maintained on a diet deficient in lysine, methionine, threonine and vitamins A, C, E. Long-term deficiency of these essential nutrients led to inhibition of monooxygenase induction in acute intoxication with pesticide (150 mg/kg) and to restriction of the induction in chronic intoxication (3 mg/kg) within 3 and 6 months. As a result of the intoxication highly toxic intermediate 2,4,5-trichlorophenol was accumulated in liver tissue of the animals kept on the disbalanced diet. The data obtained suggest that the increased accumulation of 2,4,5-trichlorophenol in liver tissue, as a result of intoxication with trichlorometaphos-3, potentiated the effect of essential nutrients deficiency on stimulation of the monooxygenase system.