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Войти в исследования Journal of clinical periodontology · 2017
Saliva and plasma levels of cardiac-related biomarkers in post-myocardial infarction patients.
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Rathnayake Nilminie, Buhlin Kåre, Kjellström Barbro, Klinge Bjorn, Löwbeer Christian, Norhammar Anna, Rydén Lars, Sorsa Timo, Tervahartiala Taina, Gustafsson Anders, PAROKRANK Steering Committee
Аннотация
AIM: To relate cardiac biomarkers, such as cystatin C and growth differentiation factor-15 (GDF-15) in saliva to myocardial infarction (MI) and to periodontal status, and to investigate the relation between salivary and plasma cardiac biomarkers.
MATERIALS AND METHODS: Two hundred patients with MI admitted to coronary care units and 200 matched controls without MI were included. Dental examination and collection of blood and saliva samples was performed 6-10 weeks after the MI for patients and in close proximity thereafter for controls. Analysing methods: ARCHITECT i4000SR, Immulite 2000 XPi or ELISA.
RESULTS: The mean age was 62 ± 8 years and 84% were male. Total probing pocket depth, fibrinogen, white blood cell counts and HbA1c were higher in patients than controls. GDF-15 levels correlated with most of the included clinical variables in both study groups. No correlation was found between plasma and saliva levels of cystatin C or GDF-15.
CONCLUSION: Salivary cystatin C and GDF-15 could not differentiate between MI patients and controls.
MATERIALS AND METHODS: Two hundred patients with MI admitted to coronary care units and 200 matched controls without MI were included. Dental examination and collection of blood and saliva samples was performed 6-10 weeks after the MI for patients and in close proximity thereafter for controls. Analysing methods: ARCHITECT i4000SR, Immulite 2000 XPi or ELISA.
RESULTS: The mean age was 62 ± 8 years and 84% were male. Total probing pocket depth, fibrinogen, white blood cell counts and HbA1c were higher in patients than controls. GDF-15 levels correlated with most of the included clinical variables in both study groups. No correlation was found between plasma and saliva levels of cystatin C or GDF-15.
CONCLUSION: Salivary cystatin C and GDF-15 could not differentiate between MI patients and controls.