A population of nesfatin 1-like immunoreactive (LI) cells in the mucosal layer of the canine digestive tract.

The aim of this study was to investigate for the first time nesfatin-1-like immunoreactive (LI) cells in the mucosal layer of the canine digestive tract. Distribution of nesfatin-1 - LI cell bodies and the co-localization of nesfatin-1 with somatostatin (SOM), cocaine-and amphetamine-regulated transcript peptide (CART), protein gene product 9.5 (PGP 9.5) and vasoactive intestinal peptide (VIP) were studied by immunohistochemistry in the selected parts of the canine digestive tract. Evaluation of the nesfatin 1-LI cells number has been based on the counting of cell bodies per observation field. Nesfatin-1-LI cells amounted to 0.87±0.06, 1.06±0.02, 0.85±0.11 and 0.56±0.13 in gastric fundus, duodenum, jejunum and descending colon, respectively. The co-localization of nesfatin-1 with the other substances studied was not observed. Functions of nesfatin-1 - LI cells in the canine digestive tract are unknown.