Journal of agricultural and food chemistry · 2022
Bioactive Peptides from Lupin (Lupinus angustifolius) Prevent the Early Stages of Atherosclerosis in Western Diet-Fed ApoE-/- Mice.
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Santos-Sánchez Guillermo, Cruz-Chamorro Ivan, Álvarez-Ríos Ana Isabel, Álvarez-Sánchez Nuria, Rodríguez-Ortiz Beatriz, Álvarez-López Ana Isabel, Fernández-Pachón María-Soledad, Pedroche Justo, Millán Francisco, Millán-Linares María Del Carmen, Lardone Patricia Judith, Bejarano Ignacio, Carrillo-Vico Antonio
Аннотация
We have previously reported the in vitro hypocholesterolemic, anti-inflammatory, and antioxidant effects of Alcalase-generated lupin protein hydrolysate (LPH). Given that lipoprotein deposition, oxidative stress, and inflammation are the main components of atherogenesis, we characterized the LPH composition, in silico identified LPH-peptides with activities related to atherosclerosis, and evaluated the in vivo LPH effects on atherosclerosis risk factors in a mouse model of atherosclerosis. After 15 min of Alcalase hydrolysis, peptides smaller than 8 kDa were obtained, and 259 peptides out of 278 peptides found showed biological activities related to atherosclerosis risk factors. Furthermore, LPH administration for 12 weeks reduced the plasma lipids, as well as the cardiovascular and atherogenic risk indexes. LPH also increased the total antioxidant capacity, decreased endothelial permeability, inflammatory response, and atherogenic markers. Therefore, this study describes for the first time that LPH prevents the early stages of atherosclerosis.