Immediate allergic reaction to thiocolchicoside confirmed by skin testing and basophil activation test: A case report and literature review.

BACKGROUND

Thiocolchicoside is a muscle relaxant, anti-inflammatory, and analgesic. Administered orally, intramuscularly, or topically, this drug is used in the symptomatic treatment of muscular spasms and rheumatologic disorders. Despite its extensive use, thiocolchicoside is a very rare sensitizer.

OBJECTIVE

To evaluate IgE-mediated reaction to thiocolchicoside by basophil activation test.

METHODS

Allergological work-up with skin prick tests, intradermal tests and basophil activation test with thiocolchicoside.

RESULTS

We report the first case of immediate reaction to thiocolchicoside confirmed by basophil activation test in addition to positive skin tests.

CONCLUSIONS

BAT can be considered a complementary diagnostic tool to demonstrate an IgE-mediated reaction also for muscle relaxant drugs.