Nature medicine · 2020
Xenogeneic cross-circulation for extracorporeal recovery of injured human lungs.
СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Hozain Ahmed E, O'Neill John D, Pinezich Meghan R, Tipograf Yuliya, Donocoff Rachel, Cunningham Katherine M, Tumen Andrew, Fung Kenmond, Ukita Rei, Simpson Michael T, Reimer Jonathan A, Ruiz Edward C, Queen Dawn, Stokes John W, Cardwell Nancy L, Talackine Jennifer, Kim Jinho, Snoeck Hans-Willem, Chen Ya-Wen, Romanov Alexander, Marboe Charles C, Griesemer Adam D, Guenthart Brandon A, Bacchetta Matthew, Vunjak-Novakovic Gordana
Аннотация
Patients awaiting lung transplantation face high wait-list mortality, as injury precludes the use of most donor lungs. Although ex vivo lung perfusion (EVLP) is able to recover marginal quality donor lungs, extension of normothermic support beyond 6 h has been challenging. Here we demonstrate that acutely injured human lungs declined for transplantation, including a lung that failed to recover on EVLP, can be recovered by cross-circulation of whole blood between explanted human lungs and a Yorkshire swine. This xenogeneic platform provided explanted human lungs a supportive, physiologic milieu and systemic regulation that resulted in functional and histological recovery after 24 h of normothermic support. Our findings suggest that cross-circulation can serve as a complementary approach to clinical EVLP to recover injured donor lungs that could not otherwise be utilized for transplantation, as well as a translational research platform for immunomodulation and advanced organ bioengineering.