Emerging infectious diseases · 2019
Francisella tularensis Transmission by Solid Organ Transplantation, 20171.
Клинический случайСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Nelson Christina A, Murua Christian, Jones Jefferson M, Mohler Kelli, Zhang Ying, Wiggins Landon, Kwit Natalie A, Respicio-Kingry Laurel, Kingry Luke C, Petersen Jeannine M, Brown Jennifer, Aslam Saima, Krafft Melissa, Asad Shadaba, Dagher Hikmat N, Ham John, Medina-Garcia Luis H, Burns Kevin, Kelley Walter E, Hinckley Alison F, Annambhotla Pallavi, Carifo Karen, Gonzalez Anthony, Helsel Elizabeth, Iser Joseph, Johnson Michael, Fritz Curtis L, Basavaraju Sridhar V, Tularemia in Transplant Recipients Investigation Team
Аннотация
In July 2017, fever and sepsis developed in 3 recipients of solid organs (1 heart and 2 kidneys) from a common donor in the United States; 1 of the kidney recipients died. Tularemia was suspected only after blood cultures from the surviving kidney recipient grew Francisella species. The organ donor, a middle-aged man from the southwestern United States, had been hospitalized for acute alcohol withdrawal syndrome, pneumonia, and multiorgan failure. F. tularensis subsp. tularensis (clade A2) was cultured from archived spleen tissue from the donor and blood from both kidney recipients. Whole-genome multilocus sequence typing indicated that the isolated strains were indistinguishable. The heart recipient remained seronegative with negative blood cultures but had been receiving antimicrobial drugs for a medical device infection before transplant. Two lagomorph carcasses collected near the donor's residence were positive by PCR for F. tularensis subsp. tularensis (clade A2). This investigation documents F. tularensis transmission by solid organ transplantation.