The Journal of thoracic and cardiovascular surgery · 2004
Experimental study of a new tracheal prosthesis: pored Dacron tube.
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Tsukada Hisashi, Osada Hiroaki
Аннотация
OBJECTIVE: This study was designed to evaluate how various sizes and densities of pores in Dacron tubing might enhance its utility as a tracheal prosthesis.
METHODS: A vascular prosthesis made of knitted external velour polyester was prepared for pore formation with a laser. The first set compared different pore sizes (300, 500, and 700 microm) and pore densities (25/cm(2) or 100/cm(2)). Grafts were reinforced with an externally heat-sealed silicone ring. The second set tested grafts with a pore density of 64/cm(2) and a pore size of 500 microm internally reinforced with a stainless-steel spiral stent. In all experiments, a canine mediastinal trachea 10 cartilage rings in length was resected, and the prosthesis was then implanted with an omental flap.
RESULTS: Lower pore size and density (300 microm, 25 pores/cm(2)) led to essentially no tissue ingrowth. Larger pore size (700 microm) and low density (25 pores/cm(2)) led to rapid and excessive ingrowth of granulation. Midrange pore size (500 microm) and high density (100 pores/cm(2)) invited steady tissue ingrowth, but marked luminal stenosis eventually developed. Stent-reinforced prostheses with 500-microm pores at 64 pores/cm(2), as used in the second set, maintained an average patency rate of 60% or more (range, 20%-100%) at least 12 months after implantation.
CONCLUSION: Our data show that porosity is a key factor for tissue growth through our Dacron tracheal prostheses. This artificial trachea model has led to long-term survivors up to 27 months after the operation and seems promising as a basic model for clinical tracheal repair.
METHODS: A vascular prosthesis made of knitted external velour polyester was prepared for pore formation with a laser. The first set compared different pore sizes (300, 500, and 700 microm) and pore densities (25/cm(2) or 100/cm(2)). Grafts were reinforced with an externally heat-sealed silicone ring. The second set tested grafts with a pore density of 64/cm(2) and a pore size of 500 microm internally reinforced with a stainless-steel spiral stent. In all experiments, a canine mediastinal trachea 10 cartilage rings in length was resected, and the prosthesis was then implanted with an omental flap.
RESULTS: Lower pore size and density (300 microm, 25 pores/cm(2)) led to essentially no tissue ingrowth. Larger pore size (700 microm) and low density (25 pores/cm(2)) led to rapid and excessive ingrowth of granulation. Midrange pore size (500 microm) and high density (100 pores/cm(2)) invited steady tissue ingrowth, but marked luminal stenosis eventually developed. Stent-reinforced prostheses with 500-microm pores at 64 pores/cm(2), as used in the second set, maintained an average patency rate of 60% or more (range, 20%-100%) at least 12 months after implantation.
CONCLUSION: Our data show that porosity is a key factor for tissue growth through our Dacron tracheal prostheses. This artificial trachea model has led to long-term survivors up to 27 months after the operation and seems promising as a basic model for clinical tracheal repair.