[Intravenous obsidan-induced changes of coronary venous blood flow in patients with coronary heart disease in the presence of transient myocardial ischemia].

Intravenous obsidan was evaluated for its effects on the blood flow in the coronary sinus and the major cardiac vein in 23 coronary heart disease patients with hyperkinetic central hemodynamics. The use of the drug was found to be effective when the patients had had high baseline coronary venous blood flow. At the peak of cardiac pacing, the patients with low coronary sinus blood flow on obsidan showed decreased blood flow in the ischemic myocardial portions, developed signs of left ventricular failure and diminished anginal threshold. Those with moderate baseline blood flow on obsidan displayed an insignificant increase in anginal threshold, higher blood flow was inadequate to oxygen consumption.