Italian journal of dermatology and venereology · 2025
Reticular erythematous mucinosis: a systematic review of a controversial entity.
СтатьяСистематический обзорНазвание и аннотация: Перевод пока не подготовлен
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Bigotto Gianmarco D, Piras Marco, Lenti Sveva, Podo-Brunetti Antonio, Stabile Giorgio, Guida Stefania, Rongioletti Franco
Аннотация
INTRODUCTION: Reticular erythematous mucinosis (REM) is a rare chronic dermatosis, predominantly affecting middle age women, characterized by net-like macules and patches on the chest and back. The etiology of REM is uncertain, though associations with environmental, hormonal, and autoimmune factors have been suggested.
EVIDENCE ACQUISITION: This systematic review of 62 studies, involving 129 patients, analyzes the clinical, histopathological, and therapeutic aspects of REM.
EVIDENCE SYNTHESIS: Findings indicate consistent mucin deposition in the dermis, a predominant lymphocytic infiltrate, and a frequent association with comorbidities like thyroid disorders and autoimmune diseases. Antimalarial medications, particularly hydroxychloroquine, are highlighted as the most effective treatment, though the disease may relapse upon cessation.
CONCLUSIONS: This review emphasizes REM as a distinct clinical entity and underscores the need for further research to refine diagnostic criteria and treatment protocols.
EVIDENCE ACQUISITION: This systematic review of 62 studies, involving 129 patients, analyzes the clinical, histopathological, and therapeutic aspects of REM.
EVIDENCE SYNTHESIS: Findings indicate consistent mucin deposition in the dermis, a predominant lymphocytic infiltrate, and a frequent association with comorbidities like thyroid disorders and autoimmune diseases. Antimalarial medications, particularly hydroxychloroquine, are highlighted as the most effective treatment, though the disease may relapse upon cessation.
CONCLUSIONS: This review emphasizes REM as a distinct clinical entity and underscores the need for further research to refine diagnostic criteria and treatment protocols.