Systematic Review on Chemsex: Advocating for Inclusive Research and Primary Prevention.

Chemsex is a specific practice of sexualized drug use (SDU), linked mainly to the group of men who have sex with men (MSM). This practice has become a public health problem due to the increase in sexually transmitted infections and HIV. However, there are groups and aspects that require greater visibility and research. This study aims to (1) analyze whether the majority of existing studies on chemsex focus on MSM and to what extent studies have addressed other sexual orientations and gender identities; and (2) determine the characteristics and effectiveness of interventions implemented for the prevention and risk reduction associated with chemsex, excluding pre- and post-exposure prophylaxis for HIV. Following PRISMA recommendations, a systematic review was conducted in the Cochrane Library, PubMed/MEDLINE, Scopus and Web of Science databases between April and July 2024. The results were synthesized using a narrative approach and the methodological quality was evaluated of the studies included with the Mixed Methods Appraisal Tool (MMAT) instrument. The first search identified 1314 studies, 14 of them being relevant. The studies analyzed the presence of chemsex and SDU in diverse samples regarding sexual orientation and gender identity. They were plural and addressed multiple aspects that constitute the phenomenon of chemsex. The second search yielded 1985 studies, of which two met the inclusion criteria. No primary or secondary prevention interventions were recorded; however, risk prevention interventions were documented. These interventions demonstrated reductions in chemsex practices, engagement in unsafe sexual behaviors, and substance use. Chemsex reflects complex dynamics within sexually minoritized groups, influenced by gender, sexual orientation, and the collective's inherent insecurities. While risk reduction programs exist, there is a notable lack of primary prevention interventions. Expanding research to include diverse populations and developing inclusive strategies to address this phenomenon is crucial.