Systematic Evaluation of Vitamin D and the Risk of Breast Cancer Development.

BACKGROUND

Tumor is a major public health problem worldwide and poses a serious threat to human life and health. Vitamin D deficiency increases the risk of developing tumors.

SUMMARY: Epidemiological evidence supports the antitumor effect of vitamin D mainly comes from the binding of its active metabolites and vitamin D receptor to play relevant biological functions. The meta-analysis generally reported that high vitamin D status was a protective factor for breast cancer. In addition, the relationship of vitamin D-related gene polymorphisms with the tumor and the relationship between vitamin D levels and tumor occurrence and risk have also attracted much attention.

KEY MESSAGES: This paper reviews the research progress of vitamin D metabolism, potential anticancer mechanisms in the tumor microenvironment, and its relationship with the risk of different tumors, and explores the relationship between vitamin D-related gene polymorphisms and tumors, providing theoretical reference for primary prevention of future tumors.