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DOI 10.1002/alz.13344

Медицинская библиотека · Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023

Baseline neuropsychiatric symptoms and psychotropic medication use midway through data collection of the Longitudinal Early-Onset Alzheimer's Disease Study (LEADS) cohort.

Polsinelli Angelina J, Wonderlin Ryan J, Hammers Dustin B, Garcia Alex Pena, Eloyan Ani, Taurone Alexander, Thangarajah Maryanne, Beckett Laurel, Gao Sujuan, Wang Sophia, Kirby Kala, Logan Paige E, Aisen Paul, Dage Jeffrey L, Foroud Tatiana, Griffin Percy, Iaccarino Leonardo, Kramer Joel H, Koeppe Robert, Kukull Walter A, La Joie Renaud, Mundada Nidhi S, Murray Melissa E, Nudelman Kelly, Soleimani-Meigooni David N, Rumbaugh Malia, Toga Arthur W, Touroutoglou Alexandra, Vemuri Prashanthi, Atri Alireza, Day Gregory S, Duara Ranjan, Graff-Radford Neill R, Honig Lawrence S, Jones David T, Masdeu Joseph, Mendez Mario F, Womack Kyle, Musiek Erik, Onyike Chiadi U, Riddle Meghan, Rogalski Emily, Salloway Steven, Sha Sharon J, Turner Raymond S, Wingo Thomas S, Wolk David A, Carrillo Maria C, Dickerson Bradford C, Rabinovici Gil D, Apostolova Liana G, LEADS Consortium

СтатьяПоддержка NIH: внешняя программаПеревод пока не подготовлен

Аннотация

INTRODUCTION

We examined neuropsychiatric symptoms (NPS) and psychotropic medication use in a large sample of individuals with early-onset Alzheimer's disease (EOAD; onset 40-64 years) at the midway point of data collection for the Longitudinal Early-onset Alzheimer's Disease Study (LEADS).

METHODS

Baseline NPS (Neuropsychiatric Inventory - Questionnaire; Geriatric Depression Scale) and psychotropic medication use from 282 participants enrolled in LEADS were compared across diagnostic groups - amyloid-positive EOAD (n = 212) and amyloid negative early-onset non-Alzheimer's disease (EOnonAD; n = 70).

RESULTS

Affective behaviors were the most common NPS in EOAD at similar frequencies to EOnonAD. Tension and impulse control behaviors were more common in EOnonAD. A minority of participants were using psychotropic medications, and use was higher in EOnonAD.

DISCUSSION: Overall NPS burden and psychotropic medication use were higher in EOnonAD than EOAD participants. Future research will investigate moderators and etiological drivers of NPS, and NPS differences in EOAD versus late-onset AD.

Для цитирования: Polsinelli Angelina J, Wonderlin Ryan J, Hammers Dustin B, Garcia Alex Pena, Eloyan Ani, Taurone Alexander, Thangarajah Maryanne, Beckett Laurel, Gao Sujuan, Wang Sophia, Kirby Kala, Logan Paige E, Aisen Paul, Dage Jeffrey L, Foroud Tatiana, Griffin Percy, Iaccarino Leonardo, Kramer Joel H, Koeppe Robert, Kukull Walter A, La Joie Renaud, Mundada Nidhi S, Murray Melissa E, Nudelman Kelly, Soleimani-Meigooni David N, Rumbaugh Malia, Toga Arthur W, Touroutoglou Alexandra, Vemuri Prashanthi, Atri Alireza, Day Gregory S, Duara Ranjan, Graff-Radford Neill R, Honig Lawrence S, Jones David T, Masdeu Joseph, Mendez Mario F, Womack Kyle, Musiek Erik, Onyike Chiadi U, Riddle Meghan, Rogalski Emily, Salloway Steven, Sha Sharon J, Turner Raymond S, Wingo Thomas S, Wolk David A, Carrillo Maria C, Dickerson Bradford C, Rabinovici Gil D, Apostolova Liana G, LEADS Consortium. Baseline neuropsychiatric symptoms and psychotropic medication use midway through data collection of the Longitudinal Early-Onset Alzheimer's Disease Study (LEADS) cohort.. Alzheimer's & dementia : the journal of the Alzheimer's Association. 2023. DOI: 10.1002/alz.13344.

Предметные рубрики MeSH

HumansAgedAlzheimer DiseaseLongitudinal StudiesData Collection
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