Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases · 2002
[Clinical characteristics and diagnosis of Pneumocystis carinii pneumonia (PCP) in patients with the acquired immunodeficiency syndrome (AIDS)].
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Zhang Ke, Ma Daqing, Xu Bin, Zhao Dawei, Wu Hao, Hua Liwei, Qin Shulin, Xu Lianzhi
Аннотация
OBJECTIVE: To explore the clinical characteristics and the diagnostic methods for PCP in patients with AIDS.
METHODS: Twelve cases of AIDS associated PCP confirmed by sputum polymerase chain reaction (PCR) were analyzed.
RESULTS: Tuberculosis was found in 4 cases and pneumonia in 1 case of PCP. Sputum PCR was positive in all the 12 cases, of them blood PCR was positive in 9, Gomori methenamine silver stain (GMS) positive in 5 and Giemsa stain positive in 6 cases. The CD(4)(+) lymphocyte count was (5 approximately 155) x 10(6)/L, with a mean of (51 +/- 48) x 10(6)/L; the number of CD(4)(+) cells less than 100 x 10(6)/L in 10 cases (83%) with 9 cases (75%) less than 50 x 10(6)/L. The CD(4)(+)/CD(8)(+) ratio was 0.01 approximately 0.29.
CONCLUSIONS: PCP was common in patients with advanced AIDS and often co-infected with other opportunistic infections such as tuberculosis. A diagnosis of PCP should be considered if sputum PCR is positive and typical clinical manifestations are present in patients with AIDS.
METHODS: Twelve cases of AIDS associated PCP confirmed by sputum polymerase chain reaction (PCR) were analyzed.
RESULTS: Tuberculosis was found in 4 cases and pneumonia in 1 case of PCP. Sputum PCR was positive in all the 12 cases, of them blood PCR was positive in 9, Gomori methenamine silver stain (GMS) positive in 5 and Giemsa stain positive in 6 cases. The CD(4)(+) lymphocyte count was (5 approximately 155) x 10(6)/L, with a mean of (51 +/- 48) x 10(6)/L; the number of CD(4)(+) cells less than 100 x 10(6)/L in 10 cases (83%) with 9 cases (75%) less than 50 x 10(6)/L. The CD(4)(+)/CD(8)(+) ratio was 0.01 approximately 0.29.
CONCLUSIONS: PCP was common in patients with advanced AIDS and often co-infected with other opportunistic infections such as tuberculosis. A diagnosis of PCP should be considered if sputum PCR is positive and typical clinical manifestations are present in patients with AIDS.