Retinal cases & brief reports · 2012
Bilateral viral retinitis in a patient with immune deficiency because of purine nucleoside phosphorylase deficiency.
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Kumar Anupma, Ziahosseini Kimia, Saeed Muhammad Usman, Pearce Ian A, Beare Nicholas A V
Аннотация
BACKGROUND: Progressive retinal outer necrosis is a devastating viral necrotizing retinitis, which affects predominantly immunocompromised patients. We report a case in which the ocular findings led to a search for an underlying immune deficiency, established as congenital purine nucleoside phosphorylase deficiency.
METHODS: Retrospective, interventional case report.
RESULTS: We describe the clinical features and management of the disease.
CONCLUSION: This is the first report of bilateral varicella zoster virus retinitis with underlying purine nucleoside phosphorylase deficiency. It highlights the importance of thorough investigation in apparent immunocompetent patients presenting with viral retinitis, as this may indicate an undiagnosed primary immunodeficiency.
METHODS: Retrospective, interventional case report.
RESULTS: We describe the clinical features and management of the disease.
CONCLUSION: This is the first report of bilateral varicella zoster virus retinitis with underlying purine nucleoside phosphorylase deficiency. It highlights the importance of thorough investigation in apparent immunocompetent patients presenting with viral retinitis, as this may indicate an undiagnosed primary immunodeficiency.