An innovative diagnostic method for myopia using blood-based biomemristor.

Myopia has become one of the main factors affecting the healthy growth of adolescents. However, the current methods for diagnosing myopia based on physiological indicators are still blank. In this work, a memristive device with Ag/ZIF-8:PVP/FTO structure was developed using ZIF-8 as the main functional material for detecting and distinguishing physiological states associated with high myopia. We observe the as-prepared memristor exhibits a significant I-V curve with memristive characteristics, as well as stable bipolar resistance switching and voltage dependent multi mechanism conduction behavior. Furthermore, after optimizing the system parameters, a robust multi-level switching response was achieved, in which the biomemristor manufactured from blood samples of highly myopic patients showed atypical memory blockade, indicating an interruption in ions migration and trap state dynamics. In particular, the experiment using a monozygotic twin family model has shown that altered memristive behavior is closely related to phenotypic differences rather than genetic identity, highlighting the sensitivity of the device to subtle physiological changes. Therefore, this work has achieved for the first time the application of the memristor based on ZIF-8 in myopia detection, which brings great hope for early screening, phenotype stratification, and minimally invasive monitoring of pediatric and high-risk populations.