Photodiagnosis and photodynamic therapy · 2025
Accuracy of a novel ultrasound biomicroscope for measuring corneal epithelial thickness and agreement with an SD-OCT based device.
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Wang Yiran, Wan Ting, Meng Qinghao, Ning Rui, Yang Xinning, Zhang Shenrong, Savini Giacomo, Schiano-Lomoriello Domenico, Huang Jinhai, Chen Shihao
Аннотация
PURPOSE: To assess the accuracy of corneal epithelial thickness (ET) measurements in healthy and post transepithelial photorefractive keratectomy (post-T-PRK) eyes using a novel ultrasound biomicroscope (Insight 100, ArcScan, Colorado, USA) and to compare the agreement with the measurements provided by a spectral-domain optical coherence tomographer (RTVue-XR, Optovue, Fremont, CA).
METHODS: In total, 32 healthy and 38 post-T-PRK eyes were included. Three consecutive measurements of right eye were acquired with the Insight 100 VHF-UBM and RTVue-XR SD-OCT. Accuracy was analyzed using intraclass correlation coefficient (ICC), test-retest repeatability (TRT), within-subject coefficient of variation (CoV), and within-subject standard deviation (Sw). Agreement was assessed by Bland-Altman analysis and paired t-tests.
RESULTS: The precision of the normal eyes were higher than post-T-PRK eyes. Central epithelial thickness (CET) had the best repeatability and reproducibility, CoV was 0.5 %∼1.71 %. The Sw and TRT was 0.35 µm and 0.79 µm in normal eyes, 1.02 µm and 1.92 µm in post-T-PRK eyes. ETsuperior-6mm has poor repeatability in normal eyes. However, post-T-PRK eyes have the worst repeatability at ET inferior-3mm and ET temporal-3mm. Agreement of CET was excellent in both groups. The widest 95 % LoA range appeared at ETsuperior-6mm of normal and post-T-PRK eyes, with 0.72∼8.74 µm and -9.51∼7.32 µm, respectively.
CONCLUSION: The Insight 100 provides good repeatability and reproducibility for ET measurements in normal and post-T-PRK eyes. CET can be used interchangeably between Insight 100 and RTVue-XR, however, it is not recommended for other positions.
METHODS: In total, 32 healthy and 38 post-T-PRK eyes were included. Three consecutive measurements of right eye were acquired with the Insight 100 VHF-UBM and RTVue-XR SD-OCT. Accuracy was analyzed using intraclass correlation coefficient (ICC), test-retest repeatability (TRT), within-subject coefficient of variation (CoV), and within-subject standard deviation (Sw). Agreement was assessed by Bland-Altman analysis and paired t-tests.
RESULTS: The precision of the normal eyes were higher than post-T-PRK eyes. Central epithelial thickness (CET) had the best repeatability and reproducibility, CoV was 0.5 %∼1.71 %. The Sw and TRT was 0.35 µm and 0.79 µm in normal eyes, 1.02 µm and 1.92 µm in post-T-PRK eyes. ETsuperior-6mm has poor repeatability in normal eyes. However, post-T-PRK eyes have the worst repeatability at ET inferior-3mm and ET temporal-3mm. Agreement of CET was excellent in both groups. The widest 95 % LoA range appeared at ETsuperior-6mm of normal and post-T-PRK eyes, with 0.72∼8.74 µm and -9.51∼7.32 µm, respectively.
CONCLUSION: The Insight 100 provides good repeatability and reproducibility for ET measurements in normal and post-T-PRK eyes. CET can be used interchangeably between Insight 100 and RTVue-XR, however, it is not recommended for other positions.