Alzheimer's & dementia (Amsterdam, Netherlands) · 2026
Apathy and resting state functional connectivity across the Alzheimer's disease continuum.
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Rivera-Delpín Gladiliz, Palmer Phebe, Ramseyer Maximilian M, Aibel Claudia R, Yu Madeline, Munro Catherine E, Vannini Patrizia, Gatchel Jennifer R, Marshall Gad A
Аннотация
INTRODUCTION: This study examined how apathy symptoms and awareness of those symptoms relate to resting-state functional connectivity magnetic resonance imaging (rs-fcMRI) across the Alzheimer's disease (AD) continuum using network segregation metrics.
METHODS: There were eighty-three participants, including cognitively unimpaired (CU; n = 46), cognitively impaired (CI; mild cognitive impairment or AD dementia, n = 21), and mild behaviorally impaired (MBI; n = 16) individuals. Apathy was measured using the Apathy Evaluation Scale (AES)-Self, AES-Informant, and discrepancy scores (informant minus self). Models tested associations between rs-fcMRI segregation and apathy. Rs-fcMRI was computed using pairwise correlations.
RESULTS: In CI individuals, dorsal attention network segregation related to greater apathy and reduced awareness of apathy, while in those with MBI, salience network segregation was linked to less apathy.
DISCUSSION: Network-level connectivity disruptions differentially relate to apathy and reduced awareness across the AD continuum.
METHODS: There were eighty-three participants, including cognitively unimpaired (CU; n = 46), cognitively impaired (CI; mild cognitive impairment or AD dementia, n = 21), and mild behaviorally impaired (MBI; n = 16) individuals. Apathy was measured using the Apathy Evaluation Scale (AES)-Self, AES-Informant, and discrepancy scores (informant minus self). Models tested associations between rs-fcMRI segregation and apathy. Rs-fcMRI was computed using pairwise correlations.
RESULTS: In CI individuals, dorsal attention network segregation related to greater apathy and reduced awareness of apathy, while in those with MBI, salience network segregation was linked to less apathy.
DISCUSSION: Network-level connectivity disruptions differentially relate to apathy and reduced awareness across the AD continuum.