Медицинская библиотека · The Netherlands journal of medicine · 1996

The influence of PCP prophylaxis on bacteriuria incidence and resistance development to trimethoprim/sulfamethoxazole in HIV-infected patients.

van Dooyeweert D A, Schneider M M, Borleffs J C, Hoepelman A I

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Аннотация

BACKGROUND

Earlier studies have shown that men infected with HIV-1 and a CD4+ cell count below 200 mm3 are at increased risk for bacteriuria. We studied the effect of 3 Pneumocystis carinii (PCP) prophylaxis regimens (low-dose TMP/SMZ, high-dose TMP/SMZ and pentamidine aerosol) on the incidence of bacteriuria and resistance development to TMP/SMZ.

METHODS

Retrospective analysis of 103 HIV-positive patients.

RESULTS

Nine patients using pentamidine had a positive culture (32%), compared to 9 patients using low-dose TMP/SMZ (17%) and 5 patients using high-dose TMP/SMZ (22%). These differences were not significant (P = 0.207). However, almost all episodes in patients using TMP/SMZ were due to infection with a resistant strain.

CONCLUSION

PCP prophylaxis with trimethoprim/sulfamethoxazole does not significantly influence the rate of bacteriuria, probably due to the development of resistance.

Для цитирования: van Dooyeweert D A, Schneider M M, Borleffs J C, Hoepelman A I. The influence of PCP prophylaxis on bacteriuria incidence and resistance development to trimethoprim/sulfamethoxazole in HIV-infected patients.. The Netherlands journal of medicine. 1996. DOI: 10.1016/s0300-2977(96)00061-7.

Предметные рубрики MeSH

Bacteriuria Drug Resistance, Microbial Drug Therapy, Combination HIV Infections Humans Male Pneumonia, Pneumocystis Retrospective Studies Sulfamethoxazole Trimethoprim

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