The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques · 2006
Valvular heart disease in pergolide-treated Parkinson's disease.
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Scozzafava James, Takahashi Jennifer, Johnston Wendy, Puttagunta Lakshmi, Martin W R Wayne
Аннотация
BACKGROUND: A 61-year-old woman with Parkinson's disease, receiving pergolide 1.75 mg four times daily, was admitted with progressive dyspnea.
METHODS: Investigations revealed mitral and aortic regurgitation. She underwent surgical mitral replacement and aortic repair, but had a post-operative course characterized by repeated bouts of congestive heart failure.
RESULTS: Severe tricuspid valve (TV) regurgitation developed within one month after the TV was reported on echocardiography to be relatively normal. Subsequent discontinuation of pergolide was associated with symptomatic improvement.
CONCLUSIONS: This case illustrates the severity and rapidity with which cardiac valvular abnormalities can develop in patients receiving pergolide.
METHODS: Investigations revealed mitral and aortic regurgitation. She underwent surgical mitral replacement and aortic repair, but had a post-operative course characterized by repeated bouts of congestive heart failure.
RESULTS: Severe tricuspid valve (TV) regurgitation developed within one month after the TV was reported on echocardiography to be relatively normal. Subsequent discontinuation of pergolide was associated with symptomatic improvement.
CONCLUSIONS: This case illustrates the severity and rapidity with which cardiac valvular abnormalities can develop in patients receiving pergolide.