Journal of basic and clinical physiology and pharmacology · 2026
Serum copper, rubidium, selenium, strontium, and zinc and psychophysical health in adults of the Sarno river Basin: PREVES-STOP 2025 community biomonitoring results.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Scafuri Luca, Baio Raffaele, Buonerba Carlo, Crocetto Felice, Verde Antonio, Ferraioli Antonella, Riccio Vittorio, Rizzano Serena, Rizzano Sara, Pisapia Armando, Montanaro Vittorino, Ronga Emily, Romeo Giuseppe, Ruffo Antonio, Ferro Matteo, Iuliano Mauro, Trifuoggi Marco, Marano Alessandra, De Tommaso Gaetano, Conte Flavia, Di Trolio Rossella, Strianese Oriana, Vitolo Alessia, Maglione Luigia, Tarantino Paola, Stanzione Francesco, Cappuccio Francesca, Costabile Ferdinando, Di Lorenzo Giuseppe
Аннотация
OBJECTIVES: Evaluate associations between serum copper (Cu), rubidium (Rb), selenium (Se), strontium (Sr), and zinc (Zn) and psychophysical health in adults from Italy's Sarno River Basin within the 2025 PREVES-STOP program.
METHODS: Adults aged 30-65 completed validated questionnaires plus clinical evaluation and blood sampling. Elements were quantified by collision/reaction-cell inductively coupled plasma mass spectrometry (ICP-MS). Associations were evaluated using Spearman and partial Spearman correlations.
RESULTS: Significant associations included Zn and Rb associated with lower odds (odds ratio, OR) of severe fatigue - Recognizing and Estimating Signs of Tiredness (REST): Zn OR=0.38, 95 % confidence interval (CI) 0.21-0.68, q=0.02; Rb OR=0.33, 95 % CI 0.15-0.71, q=0.03 - while Sr was associated with higher well-being - the World Health Organization-5 Well-Being Index (WHO-5) OR=1.36, 95 % CI 1.12-1.65, q=0.02.
CONCLUSIONS: Findings support broader trace-element panels to inform psychophysical and cardiometabolic risk beyond classical toxic metals, complementing prior PREVES-STOP evidence on lead (Pb) and cadmium (Cd). Further investigation is warranted.
METHODS: Adults aged 30-65 completed validated questionnaires plus clinical evaluation and blood sampling. Elements were quantified by collision/reaction-cell inductively coupled plasma mass spectrometry (ICP-MS). Associations were evaluated using Spearman and partial Spearman correlations.
RESULTS: Significant associations included Zn and Rb associated with lower odds (odds ratio, OR) of severe fatigue - Recognizing and Estimating Signs of Tiredness (REST): Zn OR=0.38, 95 % confidence interval (CI) 0.21-0.68, q=0.02; Rb OR=0.33, 95 % CI 0.15-0.71, q=0.03 - while Sr was associated with higher well-being - the World Health Organization-5 Well-Being Index (WHO-5) OR=1.36, 95 % CI 1.12-1.65, q=0.02.
CONCLUSIONS: Findings support broader trace-element panels to inform psychophysical and cardiometabolic risk beyond classical toxic metals, complementing prior PREVES-STOP evidence on lead (Pb) and cadmium (Cd). Further investigation is warranted.