Revista de neurologia · 2022
[Efficacy of zonisamide in Lafora's disease case and brief review of its use in progressive myoclonic epilepsy].
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Rubio-Nazábal E, Álvarez-Pérez P, Cores-Bartolomé C, Lema-Facal T
Аннотация
INTRODUCTION: Mioclonic progressive epilepsy (MPE) includes a clinical and genetical heterogeneous group of neuro-degenerative disorders that associate spontaneous and action-induced myoclonus as well as progressive cognitive impairment. Lafora`s disease is a subtype of MPE with autosomical recessive inheritance due to a mutation in EPM2A or EPM2B genes. Seizures, especially myoclonus, are often refractary to antiepileptic drugs (AD).
CASE REPORT: In this article we report a patient with Lafora´s disease diagnosis, previously resistant to several AD tested with good and sustained response to zonisamide. Indeed, we describe a brief review about the efficacy of zonisamida in MPE.
CONCLUSION: Zonisamide may be considered as a good therapeutic alternative in MPE.
CASE REPORT: In this article we report a patient with Lafora´s disease diagnosis, previously resistant to several AD tested with good and sustained response to zonisamide. Indeed, we describe a brief review about the efficacy of zonisamida in MPE.
CONCLUSION: Zonisamide may be considered as a good therapeutic alternative in MPE.