Evaluation of Neutrophil Activity Before and After Granulocyte and Monocyte Adsorptive Apheresis in Patients With Pustular Psoriasis.

INTRODUCTION

Activated neutrophils play a crucial role in the development of neutrophilic dermatoses, including pustular psoriasis. Adsorptive granulocyte and monocyte apheresis (GMA) is an effective treatment for skin disorders. Although previous basic research has demonstrated neutrophil activation, no efficient method exists to assess it in clinical settings.

METHODS

We measured neutrophil activity in patients with GPP who underwent GMA therapy using the FLP-H4200, a newly developed neutrophil activity evaluation system. Blood samples were collected before the first and after the fifth GMA session.

RESULTS

In Case 1, which responded to GMA, the neutrophil activation value decreased from 118 603 to 26 234, reaching the normal range. In Case 2, the response to GMA was poor, and the neutrophil activation value decreased from 140 623 to 76 780, which remained significantly above the normal level.

CONCLUSION

These results suggest that the neutrophil activity evaluation system may be useful for assessing disease severity and therapeutic efficacy.