BMC research notes · 2012
Differential expression of the angiogenesis growth factors in psoriasis vulgaris.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Liew Siaw-Cheok, Das-Gupta Esha, Chakravarthi Srikumar, Wong Shew-Fung, Lee Nagarajah, Safdar Najeeb, Jamil Adawiyah
Аннотация
BACKGROUND: Angiogenesis has been reported to be one of the contributory factors to the pathogenesis of psoriasis vulgaris. This study aims to compare the expression of different angiogenesis growth factors namely (1) the vascular endothelial growth factor (VEGF) subfamily: A, B, C, D and placenta growth factor (PlGF); (2) nerve growth factor (NGF) and (3) von Willebrand factor (vWFr) in the skins of patients with psoriasis vulgaris and non-psoriatic volunteers.
RESULTS: Comparative immunohistochemistry study was performed on the paraffin-sectioned psoriatic and healthy skins with the abovementioned markers. VEGF-C (p = 0.016) and NGF (p = 0.027) were expressed intensely in the cases when compared with the controls. The NGF was the only marker that was solely expressed in the cases and absent in all the controls.
CONCLUSION: The NGF (angiogenesis) and VEGF-C (lymphangiogenesis) might play a crucial role in the pathogenesis of psoriasis vulgaris and could be researched further as potential new targeted therapies for psoriasis vulgaris.
RESULTS: Comparative immunohistochemistry study was performed on the paraffin-sectioned psoriatic and healthy skins with the abovementioned markers. VEGF-C (p = 0.016) and NGF (p = 0.027) were expressed intensely in the cases when compared with the controls. The NGF was the only marker that was solely expressed in the cases and absent in all the controls.
CONCLUSION: The NGF (angiogenesis) and VEGF-C (lymphangiogenesis) might play a crucial role in the pathogenesis of psoriasis vulgaris and could be researched further as potential new targeted therapies for psoriasis vulgaris.
Предметные рубрики MeSH
AdultBiomarkersFemaleHumansImmunohistochemistryLymphangiogenesisMaleMiddle AgedNeovascularization, PathologicNerve Growth FactorPlacenta Growth FactorPregnancy ProteinsPsoriasisSkinVascular Endothelial Growth Factor AVascular Endothelial Growth Factor BVascular Endothelial Growth Factor CVascular Endothelial Growth Factor DYoung Adultvon Willebrand Factor