A novel method based on matching pursuit decomposition of gait signals for Parkinson's disease, Amyotrophic lateral sclerosis and Huntington's disease detection.

BACKGROUND AND

OBJECTIVE

An accurate detection of neurodegenerative diseases (NDDs) definitely improves the life of patients and has attracted growing attention.

METHODS

In this paper, a general automatic method for detection of Parkinson's disease (PD), Amyotrophic lateral sclerosis (ALS) and Huntington's disease (HD) has been proposed based on the localized time-frequency information of gait signals. The new main part of the detection method is to obtain a small set of sparse coefficients for the local representation of gait signals with appropriate time and frequency resolution. For this purpose, a hybrid feature set based on sparse matching pursuit decomposition and two sets of nonlinear and linear features has been developed. Then, principal components of the proposed feature have been analyzed using a sparse coding classifier. Results The proposed approach has achieved high average accuracy rates of 93%, 94%, and 97% for PD, ALS, and HD detection, respectively.

CONCLUSIONS

The obtained results have indicated that combination of time and frequency information of the gait signals through adaptive localized window length in MP makes it more efficient in comparison with the existing time, frequency or other time-frequency gait parameters. The great potential of nonlinear sparse features for PD and HD detection and linear ones for ALS detection has also been shown.