Evaluation of novel herbal antifungal efficacy against Candida albicans isolated from oral leukoplakia.

Candida albicans infection and growing antifungal resistance are often linked with the emergence of an oral leukoplakia, a potentially malignant lesion that necessitates the implementation of alternative treatment methods. Therefore, it is of interest to compare antifungal effectiveness of Curcuma longa, Azadirachta indica and Allium sativum extracts on oral leukoplakia lesions C. albicans. Agar diffusion, MIC, biofilm inhibition and time-kill assays were done with different concentrations of ethanolic extracts as control was nystatin. The extracts that had the highest activity in the form of largest inhibition zones, least MIC and greatest biofilm activity were A. sativum. Thus, its herbal extracts particularly have a good potential when used as adjunctive antifungal agents in management of oral leukoplakia.