Science (New York, N.Y.) · 2023
Interplay between calcium and sarcomeres directs cardiomyocyte maturation during regeneration.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
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Nguyen Phong D, Gooijers Iris, Campostrini Giulia, Verkerk Arie O, Honkoop Hessel, Bouwman Mara, de Bakker Dennis E M, Koopmans Tim, Vink Aryan, Lamers Gerda E M, Shakked Avraham, Mars Jonas, Mulder Aat A, Chocron Sonja, Bartscherer Kerstin, Tzahor Eldad, Mummery Christine L, de Boer Teun P, Bellin Milena, Bakkers Jeroen
Аннотация
Zebrafish hearts can regenerate by replacing damaged tissue with new cardiomyocytes. Although the steps leading up to the proliferation of surviving cardiomyocytes have been extensively studied, little is known about the mechanisms that control proliferation and redifferentiation to a mature state. We found that the cardiac dyad, a structure that regulates calcium handling and excitation-contraction coupling, played a key role in the redifferentiation process. A component of the cardiac dyad called leucine-rich repeat-containing 10 (Lrrc10) acted as a negative regulator of proliferation, prevented cardiomegaly, and induced redifferentiation. We found that its function was conserved in mammalian cardiomyocytes. This study highlights the importance of the underlying mechanisms required for heart regeneration and their application to the generation of fully functional cardiomyocytes.