Journal of pharmacy & bioallied sciences · 2025
Effect of Saline versus Gluconate/Acetate-Buffered Solution versus Lactate-Buffered Solution on Serum Chloride Among Children.
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Khader Yunus Nadeemulla Beig, Mehek Sana, Gupta Shubhanshu
Аннотация
BACKGROUND: Intravenous (IV) fluid administration is routine in pediatric care, but fluid composition can significantly influence serum electrolyte levels. Hyperchloremia, often associated with 0.9% saline, may lead to metabolic acidosis and renal dysfunction. Balanced solutions, including gluconate/acetate-buffered and lactate-buffered fluids, are being explored for safer alternatives.
OBJECTIVE: To compare the effects of saline, gluconate/acetate-buffered, and lactate-buffered IV fluids on serum chloride levels in hospitalized children.
MATERIALS AND METHODS: A prospective observational study was conducted among pediatric in patients receiving one of three IV fluids: saline (n = 30), gluconate/acetate-buffered solution (n = 30), or lactate-buffered solution (n = 30). Serum chloride was measured at baseline and after 24 h of fluid administration. Statistical analysis was performed using ANOVA and paired t-tests.
RESULTS: Mean post-infusion chloride levels were significantly higher in the saline group (107.2 ± 3.1 mmol/L) compared to the gluconate/acetate group (103.5 ± 2.4 mmol/L) and lactate-buffered group (102.9 ± 2.8 mmol/L) (P < 0.001). Chloride elevation was most pronounced in the saline group, with associated trends toward mild acidosis.
CONCLUSION: Saline use in children is associated with greater increases in serum chloride compared to balanced solutions. Buffered fluids may be preferable for maintaining electrolyte stability in pediatric fluid therapy.
OBJECTIVE: To compare the effects of saline, gluconate/acetate-buffered, and lactate-buffered IV fluids on serum chloride levels in hospitalized children.
MATERIALS AND METHODS: A prospective observational study was conducted among pediatric in patients receiving one of three IV fluids: saline (n = 30), gluconate/acetate-buffered solution (n = 30), or lactate-buffered solution (n = 30). Serum chloride was measured at baseline and after 24 h of fluid administration. Statistical analysis was performed using ANOVA and paired t-tests.
RESULTS: Mean post-infusion chloride levels were significantly higher in the saline group (107.2 ± 3.1 mmol/L) compared to the gluconate/acetate group (103.5 ± 2.4 mmol/L) and lactate-buffered group (102.9 ± 2.8 mmol/L) (P < 0.001). Chloride elevation was most pronounced in the saline group, with associated trends toward mild acidosis.
CONCLUSION: Saline use in children is associated with greater increases in serum chloride compared to balanced solutions. Buffered fluids may be preferable for maintaining electrolyte stability in pediatric fluid therapy.