Wait Time Advantage for Transplant Candidates With HIV Who Accept Kidneys From Donors With HIV Under the HOPE Act.
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Ошибки и ограничения
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Motter Jennifer D, Hussain Sarah, Brown Diane M, Florman Sander, Rana Meenakshi M, Friedman-Moraco Rachel, Gilbert Alexander J, Stock Peter, Mehta Shikha, Mehta Sapna A, Stosor Valentina, Elias Nahel, Pereira Marcus R, Haidar Ghady, Malinis Maricar, Morris Michele I, Hand Jonathan, Aslam Saima, Schaenman Joanna M, Baddley John, Small Catherine B, Wojciechowski David, Santos Carlos A Q, Blumberg Emily A, Odim Jonah, Apewokin Senu K, Giorgakis Emmanouil, Bowring Mary Grace, Werbel William A, Desai Niraj M, Tobian Aaron A R, Segev Dorry L, Massie Allan B, Durand Christine M, HOPE in Action Investigators
Аннотация
METHODS: Using a linkage between the HOPE in Action trial (NCT03500315) and Scientific Registry of Transplant Recipients, we identified 324 candidates listed for D + kidneys (HOPE) compared with 46 025 candidates not listed for D + kidneys (non-HOPE) at the same centers between April 26, 2018, and May 24, 2022. We characterized KT rate, KT type (D + , false-positive [FP; donor with false-positive HIV testing], D - [donor without HIV], living donor [LD]) and quantified the association between HOPE enrollment and KT rate using multivariable Cox regression with center-level clustering; HOPE was a time-varying exposure.
RESULTS: HOPE candidates were more likely male individuals (79% versus 62%), Black (73% versus 35%), and publicly insured (71% versus 52%; P < 0.001). Within 4.5 y, 70% of HOPE candidates received a KT (41% D + , 34% D - , 20% FP, 4% LD) versus 43% of non-HOPE candidates (74% D - , 26% LD). Conversely, 22% of HOPE candidates versus 39% of non-HOPE candidates died or were removed from the waitlist. Median KT wait time was 10.3 mo for HOPE versus 60.8 mo for non-HOPE candidates ( P < 0.001). After adjustment, HOPE candidates had a 3.30-fold higher KT rate (adjusted hazard ratio = 3.30, 95% confidence interval, 2.14-5.10; P < 0.001).
CONCLUSIONS: Listing for D + kidneys within HOPE trials was associated with a higher KT rate and shorter wait time, supporting the expansion of this practice for candidates with HIV.