JBRA assisted reproduction · 2026
Obesity and infertility: clinical associations and implications in wom-en from Goiânia - Brazil.
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Katopodis Giovanna M, Duarte Ana Carolina M, Morais Gustavo Henrique D de, Dall'Acqua Priscila C, Ferreira Sarah H, Costa Zelma B, Martini Andresa C
Аннотация
OBJECTIVE: Obesity is a major metabolic condition linked to reduced fertility. Excess adipose tissue disrupts the neuroendocrine axis and impairs several reproduc-tive processes. Evidence shows that, even when assisted reproductive technologies are used, women with obesity experience lower oocyte recovery, fewer viable embryos, and higher rates of miscarriage and gestational complica-tions. This study evaluated the relationship between obe-sity and female infertility by analyzing in vitro fertilization outcomes.
METHODS: This quantitative, cross-sectional, retro-spective study included all in vitro fertilization cycles per-formed at a private assisted reproduction clinic in Goiânia between January and December 2022. Ethical approval was obtained from the Research Ethics Committee. After applying the inclusion and exclusion criteria, 226 cycles from women aged 24-46 years were analyzed. Logistic regression models were used to assess associations be-tween maternal and paternal body mass index and in vitro fertilization outcomes, as well as metabolic comorbidities, gestational, intrapartum, and neonatal complications, and miscarriage, prematurity, and newborn birth weight.
RESULTS: Women with overweight (body mass index ≥25kg/m2) were 2.4 times more likely to develop gesta-tional complications (odds ratio, 2.42; 95% confidence in-terval, 1.048-5.598) and 2.8 times more likely to develop neonatal complications (odds ratio, 2.80; 95% confidence interval, 1.712-6.70) compared with eutrophic women. No other significant association was identified.
CONCLUSION: Higher maternal body mass index was as-sociated with increased gestational and neonatal compli-cations, but not with in vitro fertilization success. Further research using broader clinical and anthropometric indica-tors is needed to better characterize the impact of obesity and to guide preventive strategies.
METHODS: This quantitative, cross-sectional, retro-spective study included all in vitro fertilization cycles per-formed at a private assisted reproduction clinic in Goiânia between January and December 2022. Ethical approval was obtained from the Research Ethics Committee. After applying the inclusion and exclusion criteria, 226 cycles from women aged 24-46 years were analyzed. Logistic regression models were used to assess associations be-tween maternal and paternal body mass index and in vitro fertilization outcomes, as well as metabolic comorbidities, gestational, intrapartum, and neonatal complications, and miscarriage, prematurity, and newborn birth weight.
RESULTS: Women with overweight (body mass index ≥25kg/m2) were 2.4 times more likely to develop gesta-tional complications (odds ratio, 2.42; 95% confidence in-terval, 1.048-5.598) and 2.8 times more likely to develop neonatal complications (odds ratio, 2.80; 95% confidence interval, 1.712-6.70) compared with eutrophic women. No other significant association was identified.
CONCLUSION: Higher maternal body mass index was as-sociated with increased gestational and neonatal compli-cations, but not with in vitro fertilization success. Further research using broader clinical and anthropometric indica-tors is needed to better characterize the impact of obesity and to guide preventive strategies.