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DOI 10.1038/s41531-025-01039-3

Медицинская библиотека · NPJ Parkinson's disease · 2025

A community-led initiative to de-risk and advance Parkinson's disease therapeutic targets.

Vaiana Alexandra, Behr Jonathan, Birol Ryan, Blauwendraat Cornelis, Casey Bradford, Chowdhury Kushan, Citron Martin, Crapser Joshua, Dardov Victoria, Ducotterd Fiona, Dumanis Sonya, Dunlop John, Durborow Michelle, Fiske Brian, Golden Jessica, Hannestad Jonas, Hung Wendy, Kemp Jennifer, Kleiman Robin, Knight Adam, Koemeter-Cox Andrew, Leuchter Bruce, Logsdon Bejamin A, Marreiros Rita, Miller Julie E, Mitchell Amanda, Mukherjee Pooja, Navarro Grace, Nelson Matthew R, Nikolich Karoly, Otis Tom, Polinski Nicole, Rastegar-Pouyani Shima, Reith Alastair D, Riley Ekemini, Rubin Lee, Ryten Mina, Sadick Jessica, Schwabe Tina, Sherer Todd, Silvergleid Sarah, Singleton Andrew, St Clair Lara, Stoehr Jan, Stone David J, Sullivan Julianna, Tanenbaum Nicole, Tinelli Elisa, Trimble Kate, Wang Yifei, Weninger Stacie, Wiggenhauser Nicolás, Wood Stephen, Schoepp Darryle, Buggia-Prevot Virginie, Padmanabhan Shalini, Skibinski Gaia

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Аннотация

Identifying effective therapeutic targets for Parkinson's disease (PD) is challenging, with no current disease-modifying therapies available. To address this, The Michael J. Fox Foundation for Parkinson's Research launched the Targets to Therapies (T2T) initiative, uniting experts to prioritize and validate promising targets. T2T aims to develop validation strategies, create comprehensive target data profiles, and build tools to support drug development, ultimately accelerating the discovery of new therapies for PD patients.

Для цитирования: Vaiana Alexandra, Behr Jonathan, Birol Ryan, Blauwendraat Cornelis, Casey Bradford, Chowdhury Kushan, Citron Martin, Crapser Joshua, Dardov Victoria, Ducotterd Fiona, Dumanis Sonya, Dunlop John, Durborow Michelle, Fiske Brian, Golden Jessica, Hannestad Jonas, Hung Wendy, Kemp Jennifer, Kleiman Robin, Knight Adam, Koemeter-Cox Andrew, Leuchter Bruce, Logsdon Bejamin A, Marreiros Rita, Miller Julie E, Mitchell Amanda, Mukherjee Pooja, Navarro Grace, Nelson Matthew R, Nikolich Karoly, Otis Tom, Polinski Nicole, Rastegar-Pouyani Shima, Reith Alastair D, Riley Ekemini, Rubin Lee, Ryten Mina, Sadick Jessica, Schwabe Tina, Sherer Todd, Silvergleid Sarah, Singleton Andrew, St Clair Lara, Stoehr Jan, Stone David J, Sullivan Julianna, Tanenbaum Nicole, Tinelli Elisa, Trimble Kate, Wang Yifei, Weninger Stacie, Wiggenhauser Nicolás, Wood Stephen, Schoepp Darryle, Buggia-Prevot Virginie, Padmanabhan Shalini, Skibinski Gaia. A community-led initiative to de-risk and advance Parkinson's disease therapeutic targets.. NPJ Parkinson's disease. 2025. DOI: 10.1038/s41531-025-01039-3.
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