Acute eosinophilic pneumonia with intramuscular progesterone after in vitro fertilization.

OBJECTIVE

To report an unusual case of acute eosinophilic pneumonia that was associated with IM P in oil after IVF.

DESIGN

Case report.

SETTING

Academic teaching hospital.

PATIENT(S): A 35-year-old primigravid female who developed acute eosinophilic pneumonia after administration of IM P in oil as luteal-phase support after IVF.

INTERVENTION(S): Corticosteroid therapy; replacement of IM P with intravaginal preparation.

MAIN OUTCOME MEASURE(S): Evaluation of blood eosinophil counts along with clinical symptoms and chest radiograph findings at initial presentation and throughout the hospital course.

RESULT(S): After the noted interventions, there was a marked improvement of clinical symptoms, chest radiograph findings, and eosinophilia.

CONCLUSION(S): Although allergic reactions to IM P-in-oil administration are exceedingly rare, clinicians caring for patients using these products should be aware of potential adverse reactions and subsequent management.