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DOI 10.5217/ir.2025.00133

Медицинская библиотека · Intestinal research · 2026

Colitis-associated colorectal neoplasia in ulcerative colitis with primary sclerosing cholangitis: a nationwide study.

Komatsu Koichi, Shinagawa Takahide, Uchino Motoi, Ikeuchi Hiroki, Okabayashi Koji, Oka Shiro, Futami Kitaro, Itabashi Michio, Watanabe Kazuhiro, Shibutani Masatsune, Okita Yoshiki, Wakai Toshifumi, Mizuuchi Yusuke, Okamoto Kinya, Yamada Kazutaka, Sato Yu, Ogino Takayuki, Kimura Hideaki, Takahashi Kenichi, Hida Koya, Kinugasa Yusuke, Ishida Fumio, Okuda Junji, Daito Koji, Yamamoto Takayuki, Yamamoto Seiichiro, Koyama Fumikazu, Hanai Tsunekazu, Komori Koji, Shida Dai, Arakaki Junya, Akagi Yoshito, Yamaguchi Shigeki, Ueno Hideki, Matsuda Keiji, Maemoto Atsuo, Nezu Riichiro, Sasaki Shin, Sunami Eiji, Noguchi Tatsuki, Sugihara Kenichi, Ajioka Yoichi, Ishihara Soichiro, Study Group for Inflammatory Bowel Disease Associated Intestinal Cancers by the Japanese Society for Cancer of the Colon and Rectum

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Аннотация

BACKGROUND/AIMS: Ulcerative colitis (UC)-associated colorectal neoplasia (UCAN) in patients with UC and primary sclerosing cholangitis (PSC) has not been studied well in Japan. This retrospective study examined the clinicopathological features and prognosis of UCAN in patients with PSC-UC.

METHODS

A total of 808 patients with UCAN were enrolled from 1983 to 2020 and categorized into PSC (PSC-UCAN, n = 26) and no PSC (UCAN-alone, n = 782) groups. Clinicopathological features were compared between the 2 groups, and the 10-year overall survival (OS) and cancer-specific survival (CSS) were analyzed.

RESULTS

The PSC-UCAN group had a shorter UC duration before UCAN diagnosis (12.8 years vs. 16.9 years, P= 0.044), were younger at UCAN diagnosis (47.8 years vs. 53.3 years, P= 0.046), and developed UCAN more frequently in the right-sided colon (34.6% vs. 15.9%, P= 0.028) than the UCAN-alone group. The PSC-UCAN group showed a trend toward a lower proportion of high-grade dysplasia (19.2% vs. 30.7%) and a higher proportion of early-stage cancers (53.9% vs. 31.2%). The 10-year OS (64.6% vs. 79.3%, P=0.080) and CSS (80.8% vs. 83.9%, P=0.60) were comparable.

CONCLUSIONS

Patients with PSC-UCAN showed earlier and younger development of UCAN than patients with only UCAN, with a high prevalence in the right-sided colon. Early-stage cancer was more frequently observed in the PSC-UCAN group, despite the shorter duration of UC. Patients with PSC-UC probably benefit from early initiation of surveillance colonoscopy.

Для цитирования: Komatsu Koichi, Shinagawa Takahide, Uchino Motoi, Ikeuchi Hiroki, Okabayashi Koji, Oka Shiro, Futami Kitaro, Itabashi Michio, Watanabe Kazuhiro, Shibutani Masatsune, Okita Yoshiki, Wakai Toshifumi, Mizuuchi Yusuke, Okamoto Kinya, Yamada Kazutaka, Sato Yu, Ogino Takayuki, Kimura Hideaki, Takahashi Kenichi, Hida Koya, Kinugasa Yusuke, Ishida Fumio, Okuda Junji, Daito Koji, Yamamoto Takayuki, Yamamoto Seiichiro, Koyama Fumikazu, Hanai Tsunekazu, Komori Koji, Shida Dai, Arakaki Junya, Akagi Yoshito, Yamaguchi Shigeki, Ueno Hideki, Matsuda Keiji, Maemoto Atsuo, Nezu Riichiro, Sasaki Shin, Sunami Eiji, Noguchi Tatsuki, Sugihara Kenichi, Ajioka Yoichi, Ishihara Soichiro, Study Group for Inflammatory Bowel Disease Associated Intestinal Cancers by the Japanese Society for Cancer of the Colon and Rectum. Colitis-associated colorectal neoplasia in ulcerative colitis with primary sclerosing cholangitis: a nationwide study.. Intestinal research. 2026. DOI: 10.5217/ir.2025.00133.
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