The concentration of serum creatine-kinase in manic attacks of primary affective psychoses.

The study aims to observe whether subjects with a primary affective disease and manic attacks show modifications of serum concentration of creatine-kinase conferring it the role of a biologic marker. Serum concentration of creatine-kinase was determined for 122 men with mono- and bipolar affective disease during the different stages as well as for schizophrenic men with different clinical forms excepting the affective form. The control group included 60 men. Data indicated that enzyme concentration can constitute a biological marker for a primary affective disease also showing the differences between the different stages of the disease (mania, hypomania, depression and the symptom-free intervals).