Pillars of long-term antiretroviral therapy success.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
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Taramasso Lucia, Andreoni Massimo, Antinori Andrea, Bandera Alessandra, Bonfanti Paolo, Bonora Stefano, Borderi Marco, Castagna Antonella, Cattelan Anna Maria, Celesia Benedetto Maurizio, Cicalini Stefania, Cingolani Antonella, Cossarizza Andrea, D'Arminio Monforte Antonella, D'Ettorre Gabriella, Di Biagio Antonio, Di Giambenedetto Simona, Di Perri Giovanni, Esposito Vincenzo, Focà Emanuele, Gervasoni Cristina, Gori Andrea, Gianotti Nicola, Guaraldi Giovanni, Gulminetti Roberto, Lo Caputo Sergio, Madeddu Giordano, Maggi Paolo, Marandola Giorgio, Marchetti Giulia Carla, Mastroianni Claudio Maria, Mussini Cristina, Perno Carlo Federico, Rizzardini Giuliano, Rusconi Stefano, Santoro Maria, Sarmati Loredana, Zazzi Maurizio, Maggiolo Franco
Аннотация
METHODS: With the aim of identifying open questions and answers about the current controversies in modern ART, we adapted the Design Thinking methodology to the needs of the design phase of a scientific article, involving a team of experts in HIV care.
RESULTS: Five main pillars of treatment success were discussed: sustained virologic suppression over time; immunological recovery; pharmacological attributes; long-term tolerability and safety of ART; and people's satisfaction and quality of life. The definition of the outcomes to be achieved in each thematic area and the tools to achieve them were reviewed and discussed.
CONCLUSIONS: Long-term treatment success should be intended as a combination of HIV-RNA suppression, immune recovery, and high quality of life. To achieve this, the regimen should be well-tolerated, with high potency, genetic barrier, and forgiveness, and should be tailored by a person-centered perspective, based on individual needs, preferences, and therapeutic history.