Staging and response of sternal histoplasmosis by 18F-FDG PET/CT.

Histoplasmosis, a granulomatous mycosis caused by the fungus Histoplasma capsulatum, is known to primarily affect the lungs and the immune system, with involvement of skeletal system as a rare manifestation, in which case the disease usually assumes multifocality. We present a singular case of a young man diagnosed to have an isolated skeletal histoplasmosis involving the body of sternum where 18F-FDG PET/CT played major role in both diagnosis and in response evaluation to antifungal therapy.