Clinical radiology · 2025
Prognostic value of rotational mechanics derived from cardiac magnetic resonance (CMR)-feature tracking in light-chain cardiac amyloidosis and heart failure.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Zheng Y, Li Y, Li J, Yang K, Chen X, Zhao K, Dong W, Lu M, Li R, Zhao S
Аннотация
AIM: Few studies exist on myocardial torsion mechanics in light-chain cardiac amyloidosis (AL-CA) and heart failure (HF). This study evaluated the prognostic utility of torsion mechanics in AL-CA and HF.
MATERIALS AND METHODS: The data of 100 AL-CA and HF patients undergoing cardiovascular magnetic resonance (2011-2019) were retrospectively reviewed. Biventricular function, late gadolinium enhancement (LGE), and torsion mechanics parameters were analyzed. Primary endpoint was all-cause mortality.
RESULTS: Sixty-six cardiac events occurred (66 deaths) during a mean follow-up of 16.7 months (IQR 4.7-45.9). Nonsurvivors exhibited greater relative LGE mass (47.2% vs 38.0%, P=0.032), and impaired torsional mechanics: torsion (0.88 deg/cm vs 1.88 deg/cm) and peak diastolic torsion rate (-6.9 deg/cm∗s vs -8.7 deg/cm∗s; both P < 0.05). Receiver operating characteristic (ROC) analysis identified torsion≤ 1.0 deg/cm (AUC=0.70) as optimal threshold. Multivariable Cox analysis demonstrated torsion (HR=0.44, 95% CI: 0.23-0.83; P=0.011) and diastolic torsion rate (HR=0.87, 95% CI: 0.80-0.96; P=0.006) as independent predictors of all-cause mortality, providing incremental prognostic value over LGE mass (χ2 improvement: 19.9-23.4; P < 0.05).
CONCLUSION: Cardiac magnetic resonance (CMR)-derived torsion mechanics independently predict mortality in AL-CA and HF and enhance risk stratification beyond conventional markers (New York Heart Association [NYHA] functional class, LGE mass).
MATERIALS AND METHODS: The data of 100 AL-CA and HF patients undergoing cardiovascular magnetic resonance (2011-2019) were retrospectively reviewed. Biventricular function, late gadolinium enhancement (LGE), and torsion mechanics parameters were analyzed. Primary endpoint was all-cause mortality.
RESULTS: Sixty-six cardiac events occurred (66 deaths) during a mean follow-up of 16.7 months (IQR 4.7-45.9). Nonsurvivors exhibited greater relative LGE mass (47.2% vs 38.0%, P=0.032), and impaired torsional mechanics: torsion (0.88 deg/cm vs 1.88 deg/cm) and peak diastolic torsion rate (-6.9 deg/cm∗s vs -8.7 deg/cm∗s; both P < 0.05). Receiver operating characteristic (ROC) analysis identified torsion≤ 1.0 deg/cm (AUC=0.70) as optimal threshold. Multivariable Cox analysis demonstrated torsion (HR=0.44, 95% CI: 0.23-0.83; P=0.011) and diastolic torsion rate (HR=0.87, 95% CI: 0.80-0.96; P=0.006) as independent predictors of all-cause mortality, providing incremental prognostic value over LGE mass (χ2 improvement: 19.9-23.4; P < 0.05).
CONCLUSION: Cardiac magnetic resonance (CMR)-derived torsion mechanics independently predict mortality in AL-CA and HF and enhance risk stratification beyond conventional markers (New York Heart Association [NYHA] functional class, LGE mass).