13th Tuscany Retreat on Cancer Research and Apoptosis: Genetic profiling, resistance mechanisms and novel treatment concepts in cancer and neurodegeneration.

The 13th edition of the Tuscany Retreat on Cancer Research and Apoptosis was convened on August 23rd to 30th, 2025, continuing its tradition as a biennial forum for scientific exchange. The Retreat brought together leading investigators focused on cancer biology, programmed cell death, and neurodegenerative disorders. Presentations and discussions encompassed diverse themes, including mechanisms of therapeutic resistance, advances in molecular signaling networks, and the identification of novel cellular targets. All topics were unified by their relevance to the regulation of programmed cell death and the pathological consequences of its disruption. Through this review, we intend to convey the essence of the scientific exchanges and to summarize the major take-home messages derived from the Retreat.