Semi-Supervised Breast Lesion Segmentation Using Confidence-Ranked Features and Bi-Level Prototypes.

Automated lesion segmentation through breast ultrasound (BUS) images is an essential prerequisite in computer-aided diagnosis. However, the task of breast segmentation remains challenging, due to the time-consuming and labor-intensive process of acquiring precise labeled data, as well as severely ambiguous lesion boundaries and low contrast in BUS images. In this article, we propose a novel semi-supervised breast segmentation framework based on confidence-ranked features and bi-level prototypes (CoBiNet) to alleviate these issues. Our outputs are derived from two branches: classifier and projector. In the projector branch, we first rank the features by multilevel sampling to obtain multiple feature sets with different confidence levels. Then, these sets are progressed in two directions. One is to acquire local prototypes at each level by local sampling and perform trans-confidence level (TCL) contrastive learning. This encourages the low-confidence features to converge to the high-confidence features, which enhances the model's ability to recognize ambiguous regions. The other process is to generate more representative global prototypes by global sampling, followed by generating more reliable predictions and performing cross-guidance (CG) consistency learning with the classifier output predictions, facilitating knowledge transfer between the structure-aware projector and the category-discriminative classifier branches. Extensive experiments on two well-known public datasets, BUSI and UDIAT, demonstrate the superiority of our method over state-of-the-art approaches. Codes will be released upon publication.