Prospective Evaluation of Quality-of-Life Improvement After Dapagliflozin Initiation in a Greek Population With HFrEF: The EVOLUTION-HF 12-Month Results.
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Potoupni Victoria, Boulmpou Aristi, Maragkoudakis Spyridon, Briasoulis Alexandros, Foukarakis Emmanouil, Stavrati Alexia, Papadopoulos Konstantinos, Naka Katerina K, Kotsia Anna, Parissis Ioannis, Ziakas Antonios, Adamopoulos Stamatis, Tziakas Dimitrios, Patsilinakos Sotirios, Konstantinidou Melanie, Davlouros Periklis, Christogiannis Zacharias, Tsitlakidis Konstantinos, Pantelakis Ioannis, Stefanakis Georgios, Kolios Marios, Baltogiannis Ioannis, Voltyrakis Evangelos, Varounis Christos, Samothrakitis Andreas, Krikidis Dimitrios, Tsialoukis Panagiotis, Paparepa Zoe, Gourlis Dimitrios, Papoutsidakis Nikolaos, Karavidas Apostolos, Papadopoulos Christodoulos
Аннотация
METHODS: EVOLUTION-HF was an observational, multi-center, longitudinal cohort study involving 257 consecutive patients diagnosed with HFrEF who initiated dapagliflozin in a routine clinical setting in Greece. The primary objectives were to characterize baseline demographic and clinical features of patients newly initiated on dapagliflozin for HFrEF and to evaluate dapagliflozin treatment patterns, including discontinuation timing, reasons for discontinuation, and concomitant heart failure and glucose-lowering therapies over time. The secondary objectives are to describe patient-reported outcomes using the KCCQ-23 and to assess adherence to dapagliflozin among patients with HFrEF.
RESULTS: A total of 257 patients were enrolled and the follow-up period lasted for 12 months. Significant improvements among all KCCQ-23 scores were observed from baseline to 12-months post dapagliflozin initiation, revealing that the initiation and optimization of guideline-directed medical therapy in routine clinical practice provides improvement to quality of life over time.
CONCLUSIONS: Dapagliflozin was safe and well-tolerated throughout the observation period. Although benefits are observed in most patients, individuals aged > 65 years, with prior myocardial infarction, or recent hospitalizations show a diminished response, underscoring the need for tailored management and closer follow-up in these higher-risk groups.