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DOI 10.1111/irv.13167

Медицинская библиотека · Influenza and other respiratory viruses · 2023

Clinical symptoms of SARS-CoV-2 breakthrough infection during the Omicron period in relation to baseline immune status and booster vaccination-A prospective multicentre cohort of health professionals (SURPRISE study).

Kohler Philipp, Babouee Flury Baharak, Güsewell Sabine, Egger Thomas, Leal Onicio, Brucher Angela, Lemmenmeier Eva, Meier Kleeb Dorette, Möller J Carsten, Ortner Manuela, Rieder Philip, Ruetti Markus, Schmid Hans-Ruedi, Stocker Reto, Vuichard-Gysin Danielle, Speer Oliver, Wiggli Benedikt, Besold Ulrike, McGeer Allison, Risch Lorenz, Friedl Andrée, Schlegel Matthias, Vernazza Pietro, Kahlert Christian R, Kuster Stefan P, SURPRISE Study Group

Многоцентровое исследованиеСтатьяПоддержка правительства СШАПоддержка исследования: вне правительства СШАПеревод пока не подготовлен

Аннотация

The effects of different types of pre-existing immunity on the frequency of clinical symptoms caused by the SARS-CoV-2 breakthrough infection were prospectively assessed in healthcare workers during the Omicron period. Among 518 participants, hybrid immunity was associated with symptom reduction for dizziness, muscle or limb pain and headache as compared to vaccination only. Moreover, the frequencies of dizziness, cough and muscle or limb pain were lower in participants who had received a booster vaccine dose. Thus, hybrid immunity appeared to be superior in preventing specific symptoms during breakthrough infection compared to vaccination alone. A booster vaccine dose conferred additional symptom reduction.

Для цитирования: Kohler Philipp, Babouee Flury Baharak, Güsewell Sabine, Egger Thomas, Leal Onicio, Brucher Angela, Lemmenmeier Eva, Meier Kleeb Dorette, Möller J Carsten, Ortner Manuela, Rieder Philip, Ruetti Markus, Schmid Hans-Ruedi, Stocker Reto, Vuichard-Gysin Danielle, Speer Oliver, Wiggli Benedikt, Besold Ulrike, McGeer Allison, Risch Lorenz, Friedl Andrée, Schlegel Matthias, Vernazza Pietro, Kahlert Christian R, Kuster Stefan P, SURPRISE Study Group. Clinical symptoms of SARS-CoV-2 breakthrough infection during the Omicron period in relation to baseline immune status and booster vaccination-A prospective multicentre cohort of health professionals (SURPRISE study).. Influenza and other respiratory viruses. 2023. DOI: 10.1111/irv.13167.

Предметные рубрики MeSH

HumansCOVID-19SARS-CoV-2Breakthrough InfectionsDizzinessProspective StudiesVaccinationHealth PersonnelPainVaccines
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