Obstetrics and gynecology · 2023
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Antibody Titer Levels in Pregnant Individuals After Infection, Vaccination, or Both.
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Marshall Christina L, Kaplowitz Elianna, Ibroci Erona, Chung Kyle, Gigase Frederieke A J, Lieber Molly, Graziani Mara, Ohrn Sophie, Lynch Jezelle, Castro Juliana, Tubassum Rushna, Mutawakil Farida, Jessel Rebecca, Molenaar Nina, Rommel Anna-Sophie, Sperling Rhoda S, Howell Elizabeth A, Feldman Hannah, Krammer Florian, Stadlbauer Daniel, de Witte Lotje D, Bergink Veerle, Stone Joanne, Janevic Teresa, Dolan Siobhan M, Lieb Whitney
Аннотация
We examined differences in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibody responses in pregnant individuals with natural, vaccine-induced, or combined immunity. Participants had live or nonlive births between 2020 and 2022, were seropositive (SARS-CoV-2 spike protein, anti-S), and had available mRNA vaccination and infection information (n=260). We compared titer levels among three immunity profiles: 1) natural immunity (n=191), 2) vaccine-induced immunity (n=37), and 3) combined immunity (ie, natural and vaccine-induced immunity; n=32). We applied linear regression to compare anti-S titers between the groups, controlling for age, race and ethnicity, and time between vaccination or infection (whichever came last) and sample collection. Anti-S titers were 57.3% and 94.4% lower among those with vaccine-induced and natural immunity, respectively, compared with those with combined immunity ( P <.001, P =.005).