Clinical use and reporting of neurofilament quantification in neurological disorders: A global overview.
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История · было → стало
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Delaby Constance, Ladang Aurélie, Martinez-Yriarte Jose, Zecca Chiara, Logroscino Giancarlo, Körtvelyessy Peter, Tumani Hayrettin, Parchi Piero, Quadrio Isabelle, Hart Melanie, Olsen Dorte Aalund, Alcolea Daniel, Blennow Kaj, Fortea Juan, Lleo Alberto, Algeciras-Schimnich Alicia, Ayrignac Xavier, Bedel Aurélie, Santos Gustavo A A, Borelli Wyllians, Bouaziz-Amar Elodie, Baldeiras Inês, Bigot-Corbel Edith, Bjerke Maria, Carretero Perez Mercedes, Casoli Tiziana, Chabrashvili Tinatin, Chapman Miles D, Cusato Jessica, Dursun Erdinc, Fourier Anthony, Galimberti Daniela, Gezen-Ak Duygu, Gordon Brian A, Gouju Julien, de Las Heras Florez Silvia, Hernandez Sanchez Juanjo, Herwerth Marina, Imperiale Daniele, Kaczorowski Flora, Kasuga Kensaku, Keshavan Ashvini, Khalil Michael, Kuhle Jens, Leithner Christoph, Lewczuk Piotr, Letournel Franck, Tsolaki Magda, Giuffrè Guido Maria, Blanc Marie-Céline, Mroczko Barbara, Martínez Rodríguez Jose Enrique, Musso Giulia, Kulczynska-Przybik Agnieszka, Nogueira Léonor, Paquet Claire, Baiardi Simone, Gaetani Lorenzo, Parnetti Lucilla, Perez Garay Raquel, Poesen Koen, Quillard-Muraine Muriel, Rodriguez Borja Enrique, Schraen Susanna, Terracciano Daniela, Bachhuber Franziska, Halbgebauer Steffen, Tzartos Socrates, Tzartos John, Unterwalder Nadine, Vermunt Lisa, Wellington Cheryl L, Zetterberg Henrik, Teunissen Charlotte, Lehmann Sylvain
Аннотация
METHODS: We established an international working group (WG) and distributed a survey to its members to gather information on context of use (COU), (pre) analytical methods, cutoff usage, as well as the interpretation and reporting of NfL measurements.
RESULTS: Among the centers, 63% measured NfL in cerebrospinal fluid (CSF), 87% in blood, and 53% in both. COU was widespread, with 50% defining pathological cutoffs based on publications and 42% considering age. Reporting was primarily done through numeric results (95%).
DISCUSSION: Harmonizing cutoffs, reporting, and interpretation across various clinical contexts will facilitate the incorporation of this biomarker into routine clinical practice.
HIGHLIGHTS: Unique international overview of current analytical and post-analytical methods for neurofilament light chain (NfL) measurement in routine clinical practice. Tailored sheets for each neurological application. Strategies to harmonize cutoffs, reporting, and interpretation of NfL's measurement.