Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2012
[Expression of TMEM16A in gastric carcinoma and its clinical implications].
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Yang Jun, Liu Ni, Kang Anjing, Jin Yaofeng, Wang Junning, Su Baoshan, Chen Xiaoli, Li Zongfang
Аннотация
OBJECTIVE: To investigate the expression of TMEM16A in gastric carcinoma and its clinical implications.
METHODS: A total of 72 surgical specimens of gastric carcinoma were collected for examination of TMEM16A expression with immunohistochemical staining.
RESULTS: TMEM16A expression was detected in the cytoplasm and cell membrane of the tumor cells. Of the 72 specimens of the tumor tissues, the total positivity rate of TMEM16A expression was 80.56% (58/72), significantly higher than the rate in the adjacent tissues (4.17%, 3/72, P<0.005).
CONCLUSION: Aberrant expression of TMEM16A occurs in the majority of gastric carcinoma cases. TMEM16A can be used as a new candidate target for diagnosis and treatment of gastric carcinoma.
METHODS: A total of 72 surgical specimens of gastric carcinoma were collected for examination of TMEM16A expression with immunohistochemical staining.
RESULTS: TMEM16A expression was detected in the cytoplasm and cell membrane of the tumor cells. Of the 72 specimens of the tumor tissues, the total positivity rate of TMEM16A expression was 80.56% (58/72), significantly higher than the rate in the adjacent tissues (4.17%, 3/72, P<0.005).
CONCLUSION: Aberrant expression of TMEM16A occurs in the majority of gastric carcinoma cases. TMEM16A can be used as a new candidate target for diagnosis and treatment of gastric carcinoma.