[Zhonghua yan ke za zhi] Chinese journal of ophthalmology · 1999
[An experimental study of anti-angiogenesis with a cartilage-derived inhibitor].
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Gao X, Lou Y, Xi S, Feng W
Аннотация
OBJECTIVE: To evaluate the efficacy of a cartilage-derived inhibitor for the treatment of corneal neovascularization in vivo.
METHODS: A cartilage-derived inhibitor (CDI) from bovine scapula was purified to homogeneity. By rabbit corneal neovascularization (CNV) model, the effect of inhibition of CDI under various conditions was determined in corneal micropocket analysis.
RESULTS: The purified CDI could inhibit strongly the growing speed and area of rabbit CNV compared to control (P < 0.001).
CONCLUSION: It is demonstrated that CDI is a potent dose-dependent inhibitor of angiogenesis.
METHODS: A cartilage-derived inhibitor (CDI) from bovine scapula was purified to homogeneity. By rabbit corneal neovascularization (CNV) model, the effect of inhibition of CDI under various conditions was determined in corneal micropocket analysis.
RESULTS: The purified CDI could inhibit strongly the growing speed and area of rabbit CNV compared to control (P < 0.001).
CONCLUSION: It is demonstrated that CDI is a potent dose-dependent inhibitor of angiogenesis.